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This metabolite also has an affinity for the PDE receptors, about 40% of that of Cenforce 100. The major product of metabolisation by these enzymes is N-desmethylated Cenforce 100, which is metabolised further. 33 Robert F. Furchgott , Ferid Murad , and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.
The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo. No significant interactions were shown with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolized by CYP2C9. Cenforce 100 is a weak inhibitor of the CYP isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 > 150 μM).
These effects on the metabolite are not expected to be of clinical consequence. The AUC of the active metabolite, N-desmethyl Cenforce 100, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. This is consistent with ritonavir's marked effects on a broad range of P450 substrates.
Cenforce 100 metabolism is principally mediated by CYP3A4 (major route) and CYP2C9 (minor route). Due to age-differences in plasma protein binding, the corresponding increase in the AUC of free (unbound) Cenforce 100 and its active N-desmethyl metabolite were 45% and 57%, respectively see DOSAGE AND ADMINISTRATION , and Use In Specific Populations The major circulating metabolite results from N-desmethylation of Cenforce 100, and is itself further metabolized.http://mycenforce.net/http://cenforce.name/